ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.178T>C (p.Leu60=) (rs35819209)

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Total submissions: 8
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000126838 SCV000214176 likely benign Hereditary cancer-predisposing syndrome 2015-01-06 criteria provided, single submitter clinical testing
Color RCV000126838 SCV000537511 likely benign Hereditary cancer-predisposing syndrome 2015-12-28 criteria provided, single submitter clinical testing
Counsyl RCV000412370 SCV000488979 likely benign Hereditary nonpolyposis colorectal cancer type 5 2016-07-29 criteria provided, single submitter clinical testing
GeneDx RCV000212625 SCV000170366 benign not specified 2014-03-03 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000122954 SCV000166214 benign Hereditary nonpolyposis colon cancer 2017-12-26 criteria provided, single submitter clinical testing
PreventionGenetics RCV000679218 SCV000805849 likely benign not provided 2017-04-21 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000212625 SCV000601516 likely benign not specified 2017-02-08 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000679218 SCV000889459 likely benign not provided 2018-05-22 criteria provided, single submitter clinical testing

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