ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.1875C>T (p.Ser625=) (rs63749886)

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Total submissions: 10
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000162760 SCV000213237 likely benign Hereditary cancer-predisposing syndrome 2015-01-22 criteria provided, single submitter clinical testing
Color RCV000162760 SCV000690231 benign Hereditary cancer-predisposing syndrome 2015-10-29 criteria provided, single submitter clinical testing
Counsyl RCV000663035 SCV000786072 likely benign Hereditary nonpolyposis colorectal cancer type 5 2018-02-23 criteria provided, single submitter clinical testing
Department of Pathology and Laboratory Medicine,Sinai Health System RCV000504553 SCV000592593 benign not specified 2015-03-11 criteria provided, single submitter clinical testing
Illumina Clinical Services Laboratory,Illumina RCV000074695 SCV000430965 uncertain significance Lynch syndrome 2016-06-14 criteria provided, single submitter clinical testing
International Society for Gastrointestinal Hereditary Tumours (InSiGHT) RCV000074695 SCV000107899 likely benign Lynch syndrome 2018-10-18 reviewed by expert panel curation Multifactorial likelihood analysis posterior probability 0.001-0.049 (0.029)
Invitae RCV000524124 SCV000252626 benign Hereditary nonpolyposis colon cancer 2017-12-19 criteria provided, single submitter clinical testing
Mendelics RCV000074695 SCV000837890 likely benign Lynch syndrome 2018-07-02 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000504553 SCV000601522 likely benign not specified 2017-05-02 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000759847 SCV000889463 likely benign not provided 2017-05-02 criteria provided, single submitter clinical testing

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