ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.2006T>C (p.Ile669Thr) (rs555209664)

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Total submissions: 6
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000130794 SCV000185688 uncertain significance Hereditary cancer-predisposing syndrome 2017-12-05 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Insufficient or conflicting evidence,Rare (0.1%) in general population databases (dbsnp, esp, 1000 genomes)
Color RCV000130794 SCV000685247 uncertain significance Hereditary cancer-predisposing syndrome 2018-08-29 criteria provided, single submitter clinical testing
International Society for Gastrointestinal Hereditary Tumours (InSiGHT) RCV000074701 SCV000107908 uncertain significance Lynch syndrome 2013-09-05 reviewed by expert panel research Insufficient evidence
Invitae RCV000524129 SCV000254288 likely benign Hereditary nonpolyposis colon cancer 2018-01-10 criteria provided, single submitter clinical testing
PreventionGenetics RCV000679222 SCV000805855 uncertain significance not provided 2017-03-31 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000507463 SCV000601525 uncertain significance not specified 2016-11-30 criteria provided, single submitter clinical testing

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