ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.2289T>C (p.Asp763=) (rs137946937)

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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000465402 SCV000561496 likely benign Hereditary nonpolyposis colon cancer 2017-10-17 criteria provided, single submitter clinical testing
Ambry Genetics RCV000567043 SCV000662420 likely benign Hereditary cancer-predisposing syndrome 2015-11-27 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Synonymous alterations with insufficient evidence to classify as benign
GeneDx RCV000604490 SCV000732144 likely benign not specified 2017-02-09 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color RCV000567043 SCV000906643 likely benign Hereditary cancer-predisposing syndrome 2017-11-01 criteria provided, single submitter clinical testing

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