Submissions for variant NM_000179.2(MSH6):c.2289T>C (p.Asp763=) (rs137946937)

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Total submissions: 4

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Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Invitae	RCV000465402	SCV000561496	likely benign	Hereditary nonpolyposis colon cancer	2017-10-17	criteria provided, single submitter	clinical testing
Ambry Genetics	RCV000567043	SCV000662420	likely benign	Hereditary cancer-predisposing syndrome	2015-11-27	criteria provided, single submitter	clinical testing	Lines of evidence used in support of classification: Synonymous alterations with insufficient evidence to classify as benign
GeneDx	RCV000604490	SCV000732144	likely benign	not specified	2017-02-09	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color	RCV000567043	SCV000906643	likely benign	Hereditary cancer-predisposing syndrome	2017-11-01	criteria provided, single submitter	clinical testing

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