ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.267C>T (p.Asp89=) (rs762818044)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000431908 SCV000513675 likely benign not specified 2015-10-26 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000630269 SCV000751225 likely benign Hereditary nonpolyposis colon cancer 2019-12-31 criteria provided, single submitter clinical testing
Integrated Genetics/Laboratory Corporation of America RCV000431908 SCV000919731 likely benign not specified 2019-08-29 criteria provided, single submitter clinical testing
Ambry Genetics RCV001016310 SCV001177254 likely benign Hereditary cancer-predisposing syndrome 2018-11-01 criteria provided, single submitter clinical testing Synonymous alterations with insufficient evidence to classify as benign
Color RCV001016310 SCV001352503 likely benign Hereditary cancer-predisposing syndrome 2019-05-08 criteria provided, single submitter clinical testing

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