ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.2775A>G (p.Gly925=) (rs587779248)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000216149 SCV000275219 likely benign Hereditary cancer-predisposing syndrome 2015-04-16 criteria provided, single submitter clinical testing
GeneDx RCV000429794 SCV000518130 likely benign not specified 2016-04-28 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color RCV000216149 SCV000685323 likely benign Hereditary cancer-predisposing syndrome 2016-06-05 criteria provided, single submitter clinical testing
Invitae RCV000630300 SCV000751256 likely benign Hereditary nonpolyposis colon cancer 2018-01-03 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000759853 SCV000889474 likely benign not provided 2018-03-02 criteria provided, single submitter clinical testing

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