ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.3265T>C (p.Leu1089=) (rs34490141)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000164765 SCV000215441 benign Hereditary cancer-predisposing syndrome 2014-07-11 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: General population or subpopulation frequency is too high to be a pathogenic mutation based on disease/syndrome prevalence and penetrance
Color RCV000164765 SCV000685381 likely benign Hereditary cancer-predisposing syndrome 2015-04-25 criteria provided, single submitter clinical testing
Integrated Genetics/Laboratory Corporation of America RCV000589050 SCV000695848 benign not provided 2016-01-12 criteria provided, single submitter clinical testing
Invitae RCV000206704 SCV000259406 benign Hereditary nonpolyposis colon cancer 2017-11-01 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000589050 SCV000888270 benign not provided 2018-03-05 criteria provided, single submitter clinical testing

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