ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.333C>T (p.Tyr111=) (rs786202772)

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Total submissions: 7
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000165755 SCV000216499 likely benign Hereditary cancer-predisposing syndrome 2014-09-17 criteria provided, single submitter clinical testing
Invitae RCV000524171 SCV000283799 benign Hereditary nonpolyposis colorectal neoplasms 2019-12-31 criteria provided, single submitter clinical testing
Illumina Clinical Services Laboratory,Illumina RCV000226058 SCV000430949 uncertain significance Lynch syndrome 2016-06-14 criteria provided, single submitter clinical testing
Counsyl RCV000410069 SCV000487789 likely benign Hereditary nonpolyposis colorectal cancer type 5 2015-11-17 criteria provided, single submitter clinical testing
Color RCV000165755 SCV000685390 likely benign Hereditary cancer-predisposing syndrome 2016-03-02 criteria provided, single submitter clinical testing
Integrated Genetics/Laboratory Corporation of America RCV000609107 SCV000695860 likely benign not specified 2019-08-29 criteria provided, single submitter clinical testing
GeneDx RCV000609107 SCV000718709 likely benign not specified 2018-01-05 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.

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