ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.3375C>G (p.Gly1125=) (rs765577023)

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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000165873 SCV000216623 likely benign Hereditary cancer-predisposing syndrome 2014-09-15 criteria provided, single submitter clinical testing
Invitae RCV000233057 SCV000283801 likely benign Hereditary nonpolyposis colon cancer 2017-11-14 criteria provided, single submitter clinical testing
GeneDx RCV000426353 SCV000513699 likely benign not specified 2018-02-23 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color RCV000165873 SCV000908418 likely benign Hereditary cancer-predisposing syndrome 2018-05-29 criteria provided, single submitter clinical testing

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