ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.3438+6T>C (rs370170322)

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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Color RCV000774608 SCV000908419 likely benign Hereditary cancer-predisposing syndrome 2016-11-10 criteria provided, single submitter clinical testing
GeneDx RCV000443780 SCV000515856 likely benign not specified 2016-05-03 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
International Society for Gastrointestinal Hereditary Tumours (InSiGHT) RCV000074855 SCV000108067 uncertain significance Lynch syndrome 2013-09-05 reviewed by expert panel research Insufficient evidence
Invitae RCV000546237 SCV000624865 uncertain significance Hereditary nonpolyposis colon cancer 2017-05-30 criteria provided, single submitter clinical testing

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