ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.3513T>C (p.Asp1171=) (rs63749834)

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Total submissions: 7
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000524179 SCV000166231 likely benign not provided 2019-02-26 criteria provided, single submitter clinical testing
Ambry Genetics RCV000163879 SCV000214468 likely benign Hereditary cancer-predisposing syndrome 2014-08-11 criteria provided, single submitter clinical testing
GeneDx RCV000433073 SCV000513700 benign not specified 2015-08-04 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color RCV000163879 SCV000690362 likely benign Hereditary cancer-predisposing syndrome 2015-05-18 criteria provided, single submitter clinical testing
Counsyl RCV000662442 SCV000784907 likely benign Hereditary nonpolyposis colorectal cancer type 5 2017-02-03 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000524179 SCV001134434 likely benign not provided 2018-12-17 criteria provided, single submitter clinical testing
Mendelics RCV000662442 SCV001135839 likely benign Hereditary nonpolyposis colorectal cancer type 5 2019-05-28 criteria provided, single submitter clinical testing

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