ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.846G>C (p.Val282=) (rs573638836)

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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000422246 SCV000528560 likely benign not specified 2016-06-02 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000457615 SCV000561432 likely benign Lynch syndrome 2016-09-27 criteria provided, single submitter clinical testing
Color RCV000774592 SCV000908360 likely benign Hereditary cancer-predisposing syndrome 2018-07-31 criteria provided, single submitter clinical testing

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