ClinVar Miner

Submissions for variant NM_000179.2(MSH6):c.984C>T (p.Ser328=) (rs138143769)

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Total submissions: 10
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000212638 SCV000170349 benign not specified 2014-02-14 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Ambry Genetics RCV000126823 SCV000213111 likely benign Hereditary cancer-predisposing syndrome 2014-06-24 criteria provided, single submitter clinical testing
Invitae RCV000197577 SCV000252632 benign Hereditary nonpolyposis colon cancer 2017-12-28 criteria provided, single submitter clinical testing
Counsyl RCV000409252 SCV000488839 likely benign Hereditary nonpolyposis colorectal cancer type 5 2016-06-29 criteria provided, single submitter clinical testing
Genetic Services Laboratory, University of Chicago RCV000212638 SCV000595846 likely benign not specified 2017-04-17 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000212638 SCV000601624 benign not specified 2017-05-01 criteria provided, single submitter clinical testing
Color RCV000126823 SCV000685532 benign Hereditary cancer-predisposing syndrome 2015-09-22 criteria provided, single submitter clinical testing
Integrated Genetics/Laboratory Corporation of America RCV000588033 SCV000695936 benign not provided 2016-01-04 criteria provided, single submitter clinical testing
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics RCV000212638 SCV000706960 likely benign not specified 2017-04-28 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000588033 SCV000889513 benign not provided 2017-05-01 criteria provided, single submitter clinical testing

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