Submissions for variant NM_000179.2(MSH6):c.984C>T (p.Ser328=) (rs138143769)

Minimum review status:		Collection method:
Minimum conflict level:
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Total submissions: 10

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Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
GeneDx	RCV000212638	SCV000170349	benign	not specified	2014-02-14	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Ambry Genetics	RCV000126823	SCV000213111	likely benign	Hereditary cancer-predisposing syndrome	2014-06-24	criteria provided, single submitter	clinical testing
Invitae	RCV000197577	SCV000252632	benign	Hereditary nonpolyposis colon cancer	2017-12-28	criteria provided, single submitter	clinical testing
Counsyl	RCV000409252	SCV000488839	likely benign	Hereditary nonpolyposis colorectal cancer type 5	2016-06-29	criteria provided, single submitter	clinical testing
Genetic Services Laboratory, University of Chicago	RCV000212638	SCV000595846	likely benign	not specified	2017-04-17	criteria provided, single submitter	clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano	RCV000212638	SCV000601624	benign	not specified	2017-05-01	criteria provided, single submitter	clinical testing
Color	RCV000126823	SCV000685532	benign	Hereditary cancer-predisposing syndrome	2015-09-22	criteria provided, single submitter	clinical testing
Integrated Genetics/Laboratory Corporation of America	RCV000588033	SCV000695936	benign	not provided	2016-01-04	criteria provided, single submitter	clinical testing
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics	RCV000212638	SCV000706960	likely benign	not specified	2017-04-28	criteria provided, single submitter	clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano	RCV000588033	SCV000889513	benign	not provided	2017-05-01	criteria provided, single submitter	clinical testing

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