ClinVar Miner

Submissions for variant NM_000179.3(MSH6):c.-14T>C

gnomAD frequency: 0.00001  dbSNP: rs1057520318
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000429658 SCV000513670 likely benign not specified 2017-09-01 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color Diagnostics, LLC DBA Color Health RCV000579734 SCV000685150 likely benign Hereditary cancer-predisposing syndrome 2015-09-09 criteria provided, single submitter clinical testing
All of Us Research Program, National Institutes of Health RCV003995969 SCV004831295 likely benign Lynch syndrome 2023-10-02 criteria provided, single submitter clinical testing

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