Submissions for variant NM_000179.3(MSH6):c.-6G>T

dbSNP: rs730881822

Total submissions: 6

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
GeneDx	RCV000160736	SCV000211374	benign	not specified	2014-08-08	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color Diagnostics, LLC DBA Color Health	RCV000580307	SCV000685151	likely benign	Hereditary cancer-predisposing syndrome	2016-07-25	criteria provided, single submitter	clinical testing
CeGaT Center for Human Genetics Tuebingen	RCV001311926	SCV001502305	likely benign	not provided	2020-12-01	criteria provided, single submitter	clinical testing
Myriad Genetics, Inc.	RCV003315963	SCV004017891	likely benign	Lynch syndrome 5	2023-02-16	criteria provided, single submitter	clinical testing	This variant is considered likely benign. Homozygosity for this variant has been confirmed in one or more individuals lacking clinical features consistent with gene-specific recessive disease, indicating that this variant is unlikely to be pathogenic.
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital	RCV000160736	SCV004024777	likely benign	not specified	2023-08-15	criteria provided, single submitter	clinical testing
All of Us Research Program, National Institutes of Health	RCV003998518	SCV004822613	likely benign	Lynch syndrome	2023-12-13	criteria provided, single submitter	clinical testing