Submissions for variant NM_000179.3(MSH6):c.1200G>A (p.Glu400=)

dbSNP: rs536884553

Total submissions: 6

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
GeneDx	RCV001704351	SCV000528567	likely benign	not provided	2019-06-03	criteria provided, single submitter	clinical testing
Invitae	RCV000458705	SCV000561435	likely benign	Hereditary nonpolyposis colorectal neoplasms	2024-02-01	criteria provided, single submitter	clinical testing
Ambry Genetics	RCV000491492	SCV000580349	likely benign	Hereditary cancer-predisposing syndrome	2016-05-16	criteria provided, single submitter	clinical testing	This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
Color Diagnostics, LLC DBA Color Health	RCV000491492	SCV000690183	likely benign	Hereditary cancer-predisposing syndrome	2017-01-19	criteria provided, single submitter	clinical testing
Sema4, Sema4	RCV000491492	SCV002535613	likely benign	Hereditary cancer-predisposing syndrome	2021-10-15	criteria provided, single submitter	curation
All of Us Research Program, National Institutes of Health	RCV004000461	SCV004843170	likely benign	Lynch syndrome	2023-11-20	criteria provided, single submitter	clinical testing