Submissions for variant NM_000179.3(MSH6):c.2682G>A (p.Gln894=)

dbSNP: rs756239543

Total submissions: 7

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Invitae	RCV000200547	SCV000253100	likely benign	Hereditary nonpolyposis colorectal neoplasms	2023-12-16	criteria provided, single submitter	clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano	RCV003477653	SCV000601539	likely benign	not provided	2023-06-04	criteria provided, single submitter	clinical testing
Ambry Genetics	RCV000569096	SCV000662492	likely benign	Hereditary cancer-predisposing syndrome	2016-07-13	criteria provided, single submitter	clinical testing	This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
Color Diagnostics, LLC DBA Color Health	RCV000569096	SCV000685310	likely benign	Hereditary cancer-predisposing syndrome	2015-11-25	criteria provided, single submitter	clinical testing
Women's Health and Genetics/Laboratory Corporation of America, LabCorp	RCV000506904	SCV002015053	likely benign	not specified	2021-10-25	criteria provided, single submitter	clinical testing
Sema4, Sema4	RCV000569096	SCV002535761	likely benign	Hereditary cancer-predisposing syndrome	2021-12-17	criteria provided, single submitter	curation
All of Us Research Program, National Institutes of Health	RCV003996953	SCV004838482	likely benign	Lynch syndrome	2023-12-13	criteria provided, single submitter	clinical testing