Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Ambry Genetics | RCV002438078 | SCV002750911 | uncertain significance | Hereditary cancer-predisposing syndrome | 2022-07-25 | criteria provided, single submitter | clinical testing | The p.I967R variant (also known as c.2900T>G), located in coding exon 4 of the MSH6 gene, results from a T to G substitution at nucleotide position 2900. The isoleucine at codon 967 is replaced by arginine, an amino acid with similar properties. This amino acid position is conserved. In addition, this alteration is predicted to be deleterious by in silico analysis. Since supporting evidence is limited at this time, the clinical significance of this alteration remains unclear. |
All of Us Research Program, |
RCV004007458 | SCV004834452 | uncertain significance | Lynch syndrome | 2024-01-11 | criteria provided, single submitter | clinical testing |