Submissions for variant NM_000179.3(MSH6):c.3477C>T (p.Tyr1159=)

dbSNP: rs398123231

Total submissions: 8

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Ambry Genetics	RCV000165527	SCV000216259	likely benign	Hereditary cancer-predisposing syndrome	2014-08-14	criteria provided, single submitter	clinical testing	This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
Invitae	RCV000524177	SCV000561477	likely benign	Hereditary nonpolyposis colorectal neoplasms	2024-01-04	criteria provided, single submitter	clinical testing
Color Diagnostics, LLC DBA Color Health	RCV000165527	SCV000690359	likely benign	Hereditary cancer-predisposing syndrome	2017-11-09	criteria provided, single submitter	clinical testing
Women's Health and Genetics/Laboratory Corporation of America, LabCorp	RCV001194334	SCV001363795	likely benign	not specified	2020-09-28	criteria provided, single submitter	clinical testing
GeneDx	RCV001682754	SCV001896104	benign	not provided	2015-03-03	criteria provided, single submitter	clinical testing
Sema4, Sema4	RCV000165527	SCV002528033	likely benign	Hereditary cancer-predisposing syndrome	2022-03-04	criteria provided, single submitter	curation
Quest Diagnostics Nichols Institute San Juan Capistrano	RCV001682754	SCV002774196	likely benign	not provided	2023-01-16	criteria provided, single submitter	clinical testing
All of Us Research Program, National Institutes of Health	RCV003997090	SCV004835076	likely benign	Lynch syndrome	2023-12-01	criteria provided, single submitter	clinical testing