ClinVar Miner

Submissions for variant NM_000179.3(MSH6):c.3483T>G (p.Pro1161=)

dbSNP: rs757064383
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000417878 SCV000531757 likely benign not specified 2016-09-14 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV002522501 SCV003494557 likely benign Hereditary nonpolyposis colorectal neoplasms 2024-01-31 criteria provided, single submitter clinical testing
All of Us Research Program, National Institutes of Health RCV004000508 SCV004823273 likely benign Lynch syndrome 2022-11-30 criteria provided, single submitter clinical testing

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