Submissions for variant NM_000179.3(MSH6):c.3801+14G>T

gnomAD frequency: 0.00002  dbSNP: rs755626529

Total submissions: 5

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
GeneDx	RCV000435913	SCV000513703	benign	not specified	2015-09-03	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color Diagnostics, LLC DBA Color Health	RCV000582623	SCV000690402	likely benign	Hereditary cancer-predisposing syndrome	2017-02-16	criteria provided, single submitter	clinical testing
Labcorp Genetics (formerly Invitae), Labcorp	RCV002061435	SCV002372959	likely benign	Hereditary nonpolyposis colorectal neoplasms	2025-01-11	criteria provided, single submitter	clinical testing
Fulgent Genetics, Fulgent Genetics	RCV002481299	SCV002797336	likely benign	Endometrial carcinoma; Lynch syndrome 5; Mismatch repair cancer syndrome 3	2022-05-24	criteria provided, single submitter	clinical testing
CHEO Genetics Diagnostic Laboratory, Children's Hospital of Eastern Ontario	RCV003150201	SCV003837658	likely benign	Breast and/or ovarian cancer	2021-09-03	criteria provided, single submitter	clinical testing