ClinVar Miner

Submissions for variant NM_000201.3(ICAM1):c.118C>T (p.Arg40Trp)

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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Center for Genomics, Ann and Robert H. Lurie Children's Hospital of Chicago RCV003224689 SCV003920033 uncertain significance Malaria, susceptibility to 2022-07-12 criteria provided, single submitter clinical testing This variant has not been reported in the literature but is present in the Genome Aggregation Database (Highest reported MAF 0.09% (14/15278) (https://gnomad.broadinstitute.org/variant/19-10274815-C-T?dataset=gnomad_r3). Evolutionary conservation and computational predictive tools for this variant are unclear. In summary, data on this variant is insufficient for disease classification. Therefore, the clinical significance of this variant is uncertain.

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