Total submissions: 3
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Clin |
RCV000329008 | SCV003915989 | benign | Glanzmann thrombasthenia | 2023-03-21 | reviewed by expert panel | curation | After a comprehensive literature search of the synonymous variant NM_000212.3(ITGB3):c.58C>T (p.Leu20=), no individuals with Glanzmann thrombasthenia were reported with the variant. This variant was observed by Ilumina as part of a predisposition screen in an ostensibly healthy population. Moreover, the variant has a minor allele frequency of 0.01438 (146/10154 alleles) in gnomAD, found in the African/African American population, which is considerably higher than the expected frequency of the disease (BA1). In silico predictor spliceAI revealed that the synonymous mutation is not expected to impact splicing. However, BP7 was not applied as the nucleotide position is conserved. In summary, this variant meets the criteria to be classified as Benign for autosomal recessive Glanzmann Thrombasthenia based on the ACMG/AMP criteria applied, as specified by the ClinGen PD VCEP: BA1 and BP4 (PD VCEP specifications version 2.1). |
Illumina Laboratory Services, |
RCV000329008 | SCV000403731 | benign | Glanzmann thrombasthenia | 2018-01-13 | criteria provided, single submitter | clinical testing | This variant was observed in the ICSL laboratory as part of a predisposition screen in an ostensibly healthy population. It had not been previously curated by ICSL or reported in the Human Gene Mutation Database (HGMD: prior to June 1st, 2018), and was therefore a candidate for classification through an automated scoring system. Utilizing variant allele frequency, disease prevalence and penetrance estimates, and inheritance mode, an automated score was calculated to assess if this variant is too frequent to cause the disease. Based on the score and internal cut-off values, a variant classified as benign is not then subjected to further curation. The score for this variant resulted in a classification of benign for this disease. |
Labcorp Genetics |
RCV000882902 | SCV001026166 | benign | not provided | 2019-12-31 | criteria provided, single submitter | clinical testing |