Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Fulgent Genetics, |
RCV005005593 | SCV005632134 | likely pathogenic | Autosomal recessive limb-girdle muscular dystrophy type 2C | 2024-01-31 | criteria provided, single submitter | clinical testing | |
Labcorp Genetics |
RCV005005593 | SCV005823613 | pathogenic | Autosomal recessive limb-girdle muscular dystrophy type 2C | 2024-02-19 | criteria provided, single submitter | clinical testing | This sequence change replaces serine, which is neutral and polar, with leucine, which is neutral and non-polar, at codon 107 of the SGCG protein (p.Ser107Leu). This variant is present in population databases (rs772017929, gnomAD 0.01%). This missense change has been observed in individual(s) with limb girdle muscular dystophy (PMID: 3076484, 36992678). In at least one individual the data is consistent with being in trans (on the opposite chromosome) from a pathogenic variant. It has also been observed to segregate with disease in related individuals. Advanced modeling of protein sequence and biophysical properties (such as structural, functional, and spatial information, amino acid conservation, physicochemical variation, residue mobility, and thermodynamic stability) performed at Invitae indicates that this missense variant is expected to disrupt SGCG protein function with a positive predictive value of 80%. For these reasons, this variant has been classified as Pathogenic. |