ClinVar Miner

Submissions for variant NM_000245.4(MET):c.2583+6A>G

gnomAD frequency: 0.00004  dbSNP: rs769647929
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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV001086662 SCV000294271 likely benign Renal cell carcinoma 2024-02-01 criteria provided, single submitter clinical testing
GeneDx RCV000828224 SCV000969908 likely benign not provided 2020-12-09 criteria provided, single submitter clinical testing
Sema4, Sema4 RCV002255343 SCV002532128 likely benign Hereditary cancer-predisposing syndrome 2022-02-09 criteria provided, single submitter curation
PreventionGenetics, part of Exact Sciences RCV004745306 SCV005347529 likely benign MET-related disorder 2024-03-09 no assertion criteria provided clinical testing This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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