ClinVar Miner

Submissions for variant NM_000245.4(MET):c.2715C>T (p.Ser905=)

gnomAD frequency: 0.00039  dbSNP: rs45572835
Minimum review status: Collection method:
Minimum conflict level:
ClinVar version:
Total submissions: 8
Download table as spreadsheet
Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV001507228 SCV000253347 benign Renal cell carcinoma 2024-01-23 criteria provided, single submitter clinical testing
Ambry Genetics RCV000566209 SCV000673716 likely benign Hereditary cancer-predisposing syndrome 2016-08-17 criteria provided, single submitter clinical testing This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
Mendelics RCV000987953 SCV001137460 likely benign Papillary renal cell carcinoma type 1 2019-05-28 criteria provided, single submitter clinical testing
GeneDx RCV001550435 SCV001770761 likely benign not provided 2020-08-25 criteria provided, single submitter clinical testing
Sema4, Sema4 RCV000566209 SCV002532136 likely benign Hereditary cancer-predisposing syndrome 2021-07-03 criteria provided, single submitter curation
CeGaT Center for Human Genetics Tuebingen RCV001550435 SCV004158934 likely benign not provided 2023-04-01 criteria provided, single submitter clinical testing MET: BP7
Breakthrough Genomics, Breakthrough Genomics RCV001550435 SCV005221495 likely benign not provided criteria provided, single submitter not provided
PreventionGenetics, part of Exact Sciences RCV003907748 SCV004723636 likely benign MET-related disorder 2022-02-10 no assertion criteria provided clinical testing This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.