ClinVar Miner

Submissions for variant NM_000245.4(MET):c.2887+3G>T

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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV002440168 SCV002749963 uncertain significance Hereditary cancer-predisposing syndrome 2022-02-10 criteria provided, single submitter clinical testing The c.2941+3G>T intronic variant results from a G to T substitution 3 nucleotides after coding exon 12 in the MET gene. This nucleotide position is not well conserved in available vertebrate species. In silico splice site analysis for this alteration is inconclusive. Since supporting evidence is limited at this time, the clinical significance of this alteration remains unclear.

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