Submissions for variant NM_000245.4(MET):c.798G>A (p.Arg266=)

gnomAD frequency: 0.00073  dbSNP: rs185301166

Total submissions: 7

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Labcorp Genetics (formerly Invitae), Labcorp	RCV000203934	SCV000259232	benign	Renal cell carcinoma	2024-01-31	criteria provided, single submitter	clinical testing
Ambry Genetics	RCV000563782	SCV000673710	likely benign	Hereditary cancer-predisposing syndrome	2016-07-21	criteria provided, single submitter	clinical testing	This alteration is classified as likely benign based on a combination of the following: seen in unaffected individuals, population frequency, intact protein function, lack of segregation with disease, co-occurrence, RNA analysis, in silico models, amino acid conservation, lack of disease association in case-control studies, and/or the mechanism of disease or impacted region is inconsistent with a known cause of pathogenicity.
GeneDx	RCV001699006	SCV000730734	likely benign	not provided	2020-10-23	criteria provided, single submitter	clinical testing	This variant is associated with the following publications: (PMID: 26375439)
Sema4, Sema4	RCV000563782	SCV002532185	likely benign	Hereditary cancer-predisposing syndrome	2022-01-04	criteria provided, single submitter	curation
Clinical Genetics, Academic Medical Center	RCV001699006	SCV001922477	likely benign	not provided		no assertion criteria provided	clinical testing
Clinical Genetics DNA and cytogenetics Diagnostics Lab, Erasmus MC, Erasmus Medical Center	RCV001699006	SCV001967124	likely benign	not provided		no assertion criteria provided	clinical testing
PreventionGenetics, part of Exact Sciences	RCV003917834	SCV004735458	likely benign	MET-related disorder	2021-12-20	no assertion criteria provided	clinical testing	This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).