Submissions for variant NM_000249.3(MLH1):c.307-29C>A (rs139620056)

Total submissions: 5

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
International Society for Gastrointestinal Hereditary Tumours (InSiGHT)	RCV000075643	SCV000106649	no known pathogenicity	Lynch syndrome	2013-09-05	reviewed by expert panel	research	Multifactorial likelihood analysis posterior probability <0.001
Institute for Biomarker Research,Medical Diagnostic Laboratories, L.L.C.	RCV000209433	SCV000679730	likely benign	Hereditary cancer-predisposing syndrome	2017-07-12	criteria provided, single submitter	clinical testing
GeneDx	RCV000829443	SCV000971173	likely benign	not provided	2018-06-17	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Mayo Clinic Genetic Testing Laboratories,Mayo Clinic	RCV000202118	SCV000257096	likely benign	not specified		no assertion criteria provided	clinical testing
University of Washington Department of Laboratory Medicine, University of Washington	RCV000209433	SCV000265270	likely benign	Hereditary cancer-predisposing syndrome	2015-12-01	no assertion criteria provided	clinical testing