ClinVar Miner

Submissions for variant NM_000249.3(MLH1):c.545+20A>T (rs121909453)

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Total submissions: 7
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000202235 SCV000170288 benign not specified 2013-10-25 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Vantari Genetics RCV000157758 SCV000267047 benign Hereditary cancer-predisposing syndrome 2015-12-21 criteria provided, single submitter clinical testing
Color RCV000157758 SCV000684841 benign Hereditary cancer-predisposing syndrome 2015-03-31 criteria provided, single submitter clinical testing
PreventionGenetics,PreventionGenetics RCV000202235 SCV000805973 benign not specified 2017-10-26 criteria provided, single submitter clinical testing
Integrated Genetics/Laboratory Corporation of America RCV000030227 SCV000052894 benign Lynch syndrome 2012-02-22 no assertion criteria provided clinical testing
Narod's Lab, University of Toronto RCV000059817 SCV000091387 not provided not provided no assertion provided not provided
Mayo Clinic Genetic Testing Laboratories,Mayo Clinic RCV000202235 SCV000257103 benign not specified no assertion criteria provided research

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