ClinVar Miner

Submissions for variant NM_000249.4(MLH1):c.307-10T>C

dbSNP: rs572853043
Minimum review status: Collection method:
Minimum conflict level:
ClinVar version:
Total submissions: 6
Download table as spreadsheet
Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000119218 SCV000153960 likely benign Hereditary nonpolyposis colorectal neoplasms 2024-01-09 criteria provided, single submitter clinical testing
Color Diagnostics, LLC DBA Color Health RCV000582091 SCV000689875 likely benign Hereditary cancer-predisposing syndrome 2017-08-10 criteria provided, single submitter clinical testing
Counsyl RCV000663206 SCV000786389 likely benign Colorectal cancer, hereditary nonpolyposis, type 2 2018-04-25 criteria provided, single submitter clinical testing
GeneDx RCV001650975 SCV001865604 likely benign not provided 2021-04-09 criteria provided, single submitter clinical testing
Myriad Genetics, Inc. RCV000663206 SCV004018153 likely benign Colorectal cancer, hereditary nonpolyposis, type 2 2023-03-14 criteria provided, single submitter clinical testing This variant is considered likely benign. This variant is intronic and is not expected to impact mRNA splicing.
All of Us Research Program, National Institutes of Health RCV003997306 SCV004831282 likely benign Lynch syndrome 2023-11-20 criteria provided, single submitter clinical testing

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.