Total submissions: 7
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Counsyl | RCV000409272 | SCV000488919 | likely benign | Colorectal cancer, hereditary nonpolyposis, type 2 | 2016-07-18 | criteria provided, single submitter | clinical testing | |
Gene |
RCV000423401 | SCV000513616 | likely benign | not specified | 2017-01-10 | criteria provided, single submitter | clinical testing | This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease. |
Color Diagnostics, |
RCV000580579 | SCV000684868 | likely benign | Hereditary cancer-predisposing syndrome | 2017-03-20 | criteria provided, single submitter | clinical testing | |
Invitae | RCV002058846 | SCV002394912 | likely benign | Hereditary nonpolyposis colorectal neoplasms | 2024-01-18 | criteria provided, single submitter | clinical testing | |
Center for Genomic Medicine, |
RCV000423401 | SCV002552443 | likely benign | not specified | 2023-08-15 | criteria provided, single submitter | clinical testing | |
Myriad Genetics, |
RCV000409272 | SCV004020258 | benign | Colorectal cancer, hereditary nonpolyposis, type 2 | 2023-03-10 | criteria provided, single submitter | clinical testing | This variant is considered benign. This variant is strongly associated with less severe personal and family histories of cancer, typical for individuals without pathogenic variants in this gene [PMID: 25085752]. |
All of Us Research Program, |
RCV003995910 | SCV004822620 | likely benign | Lynch syndrome | 2023-08-28 | criteria provided, single submitter | clinical testing |