ClinVar Miner

Submissions for variant NM_000251.2(MSH2):c.1545C>T (p.Ser515=) (rs1553366537)

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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000538098 SCV000625281 likely benign Hereditary nonpolyposis colorectal neoplasms 2019-12-31 criteria provided, single submitter clinical testing
Color RCV000584250 SCV000689994 likely benign Hereditary cancer-predisposing syndrome 2016-10-24 criteria provided, single submitter clinical testing
GeneDx RCV000602072 SCV000720826 likely benign not specified 2017-07-06 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
PreventionGenetics,PreventionGenetics RCV000679292 SCV000806002 likely benign not provided 2017-02-22 criteria provided, single submitter clinical testing

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