ClinVar Miner

Submissions for variant NM_000251.2(MSH2):c.1863A>T (p.Arg621=) (rs786203119)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000166283 SCV000217065 likely benign Hereditary cancer-predisposing syndrome 2014-10-21 criteria provided, single submitter clinical testing
Color RCV000166283 SCV000684989 likely benign Hereditary cancer-predisposing syndrome 2016-10-08 criteria provided, single submitter clinical testing
GeneDx RCV000423222 SCV000515997 likely benign not specified 2016-04-04 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000558479 SCV000625324 likely benign Hereditary nonpolyposis colon cancer 2017-08-18 criteria provided, single submitter clinical testing
PreventionGenetics RCV000679298 SCV000806015 likely benign not provided 2018-01-11 criteria provided, single submitter clinical testing

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