ClinVar Miner

Submissions for variant NM_000251.2(MSH2):c.198C>T (p.Tyr66=) (rs730881784)

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Total submissions: 6
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000160652 SCV000212860 likely benign Hereditary cancer-predisposing syndrome 2014-10-24 criteria provided, single submitter clinical testing
Color RCV000160652 SCV000537504 likely benign Hereditary cancer-predisposing syndrome 2015-11-25 criteria provided, single submitter clinical testing
Counsyl RCV000409186 SCV000489340 likely benign Lynch syndrome I 2016-09-20 criteria provided, single submitter clinical testing
Department of Pathology and Laboratory Medicine,Sinai Health System RCV000212580 SCV000592454 likely benign not specified criteria provided, single submitter clinical testing
GeneDx RCV000212580 SCV000211255 benign not specified 2014-07-28 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000206199 SCV000260791 likely benign Hereditary nonpolyposis colon cancer 2017-12-19 criteria provided, single submitter clinical testing

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