ClinVar Miner

Submissions for variant NM_000251.3(MSH2):c.1662-14A>G

dbSNP: rs764784349
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000445196 SCV000517894 likely benign not specified 2016-12-30 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Labcorp Genetics (formerly Invitae), Labcorp RCV002062292 SCV002415601 likely benign Hereditary nonpolyposis colorectal neoplasms 2024-12-24 criteria provided, single submitter clinical testing
Myriad Genetics, Inc. RCV005246951 SCV005896179 likely benign Lynch syndrome 1 2024-12-10 criteria provided, single submitter clinical testing This variant is considered likely benign. This variant is intronic and is not expected to impact mRNA splicing.

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