ClinVar Miner

Submissions for variant NM_000251.3(MSH2):c.588A>C (p.Pro196=)

dbSNP: rs1553350915
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV000537096 SCV000625440 likely benign Hereditary nonpolyposis colorectal neoplasms 2019-11-10 criteria provided, single submitter clinical testing
Women's Health and Genetics/Laboratory Corporation of America, LabCorp RCV000780449 SCV000917702 likely benign not specified 2019-08-29 criteria provided, single submitter clinical testing
Myriad Genetics, Inc. RCV005248164 SCV005897478 benign Lynch syndrome 1 2024-12-04 criteria provided, single submitter clinical testing This variant is considered benign. This variant is a silent/synonymous amino acid change and it is not expected to impact splicing.

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