Total submissions: 4
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Genetic Services Laboratory, |
RCV000011802 | SCV000193750 | pathogenic | Severe X-linked myotubular myopathy | 2013-02-08 | criteria provided, single submitter | clinical testing | |
Labcorp Genetics |
RCV000011802 | SCV002178892 | pathogenic | Severe X-linked myotubular myopathy | 2021-06-16 | criteria provided, single submitter | clinical testing | This sequence change replaces asparagine with serine at codon 189 of the MTM1 protein (p.Asn189Ser). The asparagine residue is highly conserved and there is a small physicochemical difference between asparagine and serine. This variant is not present in population databases (ExAC no frequency). This variant has been observed in individual(s) with myotubular myopathy (PMID: 8640223). In at least one individual the variant was observed to be de novo. This variant is also known as A620G, N207S. ClinVar contains an entry for this variant (Variation ID: 11053). Advanced modeling of protein sequence and biophysical properties (such as structural, functional, and spatial information, amino acid conservation, physicochemical variation, residue mobility, and thermodynamic stability) performed at Invitae indicates that this missense variant is expected to disrupt MTM1 protein function. Algorithms developed to predict the effect of sequence changes on RNA splicing suggest that this variant may create or strengthen a splice site, but this prediction has not been confirmed by published transcriptional studies. For these reasons, this variant has been classified as Pathogenic. |
Gene |
RCV004700217 | SCV005201746 | likely pathogenic | not provided | 2024-01-28 | criteria provided, single submitter | clinical testing | Not observed at significant frequency in large population cohorts (gnomAD); In silico analysis supports that this missense variant has a deleterious effect on protein structure/function; This variant is associated with the following publications: (PMID: 8640223, 10063835, Woo_2022[Article], 34011573) |
OMIM | RCV000011802 | SCV000032035 | pathogenic | Severe X-linked myotubular myopathy | 1996-06-01 | no assertion criteria provided | literature only |