Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Labcorp Genetics |
RCV000548701 | SCV000626793 | pathogenic | Glycogen storage disease IXa1 | 2024-02-23 | criteria provided, single submitter | clinical testing | This sequence change replaces threonine, which is neutral and polar, with isoleucine, which is neutral and non-polar, at codon 1114 of the PHKA2 protein (p.Thr1114Ile). This variant is not present in population databases (gnomAD no frequency). This missense change has been observed in individuals with X-linked liver glycogenosis and a glycogen storage disease and hepatomegaly (PMID: 8733133, 33763395; Invitae). It has also been observed to segregate with disease in related individuals. ClinVar contains an entry for this variant (Variation ID: 10533). Advanced modeling of protein sequence and biophysical properties (such as structural, functional, and spatial information, amino acid conservation, physicochemical variation, residue mobility, and thermodynamic stability) performed at Invitae indicates that this missense variant is expected to disrupt PHKA2 protein function with a positive predictive value of 80%. For these reasons, this variant has been classified as Pathogenic. |
OMIM | RCV000011279 | SCV000031507 | pathogenic | Glycogen storage disease IXa2 | 1996-05-01 | no assertion criteria provided | literature only |