ClinVar Miner

Submissions for variant NM_000313.4(PROS1):c.864C>T (p.Cys288=)

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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV002586701 SCV002933642 likely benign Thrombophilia due to protein S deficiency, autosomal recessive 2024-12-10 criteria provided, single submitter clinical testing
PreventionGenetics, part of Exact Sciences RCV003896234 SCV004709045 likely benign PROS1-related disorder 2021-02-15 no assertion criteria provided clinical testing This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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