ClinVar Miner

Submissions for variant NM_000314.7(PTEN):c.1008C>T (p.Tyr336=) (rs786201816)

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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000164300 SCV000214930 likely benign Hereditary cancer-predisposing syndrome 2014-05-23 criteria provided, single submitter clinical testing
Invitae RCV000542790 SCV000645542 likely benign PTEN hamartoma tumor syndrome 2017-08-31 criteria provided, single submitter clinical testing
GeneDx RCV000603547 SCV000726986 likely benign not specified 2018-01-17 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.

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