Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Women's Health and Genetics/Laboratory Corporation of America, |
RCV003387721 | SCV004099940 | pathogenic | Rh deficiency syndrome | 2023-09-18 | criteria provided, single submitter | clinical testing | Variant summary: RHAG c.1067+1G>A is located in a canonical splice-site and is predicted to affect mRNA splicing resulting in a significantly altered protein due to either exon skipping, shortening, or inclusion of intronic material. Several computational tools predict a significant impact on normal splicing: Four predict the variant abolishes a canonical 5' splicing donor site. At least one publication reports experimental evidence that this variant affects mRNA splicing (Huang_1998), finding that the variant results in skipping of exon 7 which is expected to cause a frameshift. The variant was absent in 251022 control chromosomes (gnomAD). c.1067+1G>A has been reported in the literature in a homozygous individual affected with Rh-null disease (Huang_1998) and a heterozygous individual affected with overhydrated stomatocytosis (Jamwal_2020). These data indicate that the variant is likely to be associated with disease. The following publications have been ascertained in the context of this evaluation (PMID: 9442063, 32036089). No submitters have cited clinical-significance assessments for this variant to ClinVar after 2014. Based on the evidence outlined above, the variant was classified as pathogenic. |
OMIM | RCV000013939 | SCV000034186 | pathogenic | Rh-null, regulator type | 1999-09-01 | no assertion criteria provided | literature only |