Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Broad Center for Mendelian Genomics, |
RCV003322280 | SCV004026593 | uncertain significance | Hyperinsulinemic hypoglycemia, familial, 1 | 2023-08-16 | criteria provided, single submitter | curation | The p.Val21Ile variant in ABCC8 has not been previously reported in individuals with hyperinsulinemic hypoglycemia, but has been identified in 0.0009% (1/107616) of European (non-Finnish) chromosomes by the Genome Aggregation Database (gnomAD, http://gnomad.broadinstitute.org; dbSNP rs1176097396). Although this variant has been seen in the general population in a heterozygous state, its frequency is low enough to be consistent with a recessive carrier frequency. Computational prediction tools and conservation analyses do not provide strong support for or against an impact to the protein. One additional pathogenic variant, resulting in a different amino acid change at the same position, p.Val21Asp, has been reported in association with disease in ClinVar, supporting that a change at this position may not be tolerated (Variation ID: 495835). In summary the clinical significance of the p.Val21Ile variant is uncertain. ACMG/AMP Criteria applied: PM2_supporting, PM5 (Richards 2015). |