ClinVar Miner

Submissions for variant NM_000400.4(ERCC2):c.1480-2A>C

dbSNP: rs1971989621
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV002050221 SCV002114158 pathogenic not provided 2022-10-28 criteria provided, single submitter clinical testing This sequence change affects an acceptor splice site in intron 15 of the ERCC2 gene. It is expected to disrupt RNA splicing. Variants that disrupt the donor or acceptor splice site typically lead to a loss of protein function (PMID: 16199547), and loss-of-function variants in ERCC2 are known to be pathogenic (PMID: 9238033, 11335038, 19085937, 19934020). This variant is not present in population databases (gnomAD no frequency). Disruption of this splice site has been observed in individual(s) with trichothiodystrophy (PMID: 31282071). In at least one individual the data is consistent with being in trans (on the opposite chromosome) from a pathogenic variant. It has also been observed to segregate with disease in related individuals. ClinVar contains an entry for this variant (Variation ID: 1346864). Algorithms developed to predict the effect of sequence changes on RNA splicing suggest that this variant may disrupt the consensus splice site. For these reasons, this variant has been classified as Pathogenic.
Fulgent Genetics, Fulgent Genetics RCV005023282 SCV005648401 likely pathogenic Cerebrooculofacioskeletal syndrome 2; Xeroderma pigmentosum, group D; Trichothiodystrophy 1, photosensitive 2024-03-13 criteria provided, single submitter clinical testing

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