Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Clin |
RCV000852005 | SCV001397559 | pathogenic | Glanzmann thrombasthenia | 2021-12-02 | reviewed by expert panel | curation | The NM_000419.4:c.1186G>A variant that results in the missense change, Asp396Asn, is reported at a low frequency of 0.000066 in gnomAD (PM2_supporting). It is reported in three compound heterozygous (PMID: 25373348, 34267460, and 31064749) and one apparently homozygous (PMID: 19172520) probands (PM3_strong). Probands from PMID: 25373348 and 34267460 meet criteria for PP4_strong including mucocutaneous bleeding, impaired aggregation with all agonists except ristocetin, and reduced surface expression of alphaIIbbeta3 measured by flow cytometry. It is predicted damaging by in-silico tools, with a REVEL score of 0.871. In summary, there is evidence to classify the Asp396Asn variant as Pathogenic for GT. GT-specific criteria applied: PM3_strong, PM2_Supporting, PP3, PP4_Strong. |
NIHR Bioresource Rare Diseases, |
RCV000852005 | SCV000899447 | likely pathogenic | Glanzmann thrombasthenia | 2019-02-01 | criteria provided, single submitter | research |