Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Clin |
RCV004577676 | SCV005061662 | pathogenic | Glanzmann thrombasthenia | 2024-02-20 | reviewed by expert panel | curation | The c.189-319_236del variant in ITGA2B is an intronic variant which occurs within the canonical splice acceptor site of intron 1. It is predicted to cause skipping of biologically-relevant-exon 2, resulting in a frameshift with a premature stop codon in exon 3/15, leading to nonsense mediated decay in a gene in which loss-of-function is an established disease mechanism (PVS1; PMID 31029159). This variant has been detected in at least 2 probands with Glanzmann thrombasthenia. 2 probands were homozygous for the variant (1PM3 point, PMIDs: 31029159). Total points: 1 (PM3_Moderate). This variant is absent from gnomAD SVs v4 (PM2_Supporting). In summary, this variant meets the criteria to be classified as pathogenic for autosomal recessive Glanzmann Thrombasthenia based on the ACMG/AMP criteria applied, as specified by the ClinGen PD VCEP: PVS1, PM3, PM2. |