Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Clin |
RCV001225230 | SCV001397480 | likely pathogenic | Glanzmann thrombasthenia | 2023-11-02 | reviewed by expert panel | curation | The NM_000419.5(ITGA2B):c.574+5G>C variant occurs in the donor splice region of exon 4 and is predicted to disrupt the wild-type splice donor site by SpliceAI (delta score 0.79; PP3). It is reported in the compound heterozygous state with the likely pathogenic variant, Ser160Arg (PM3) in one individual with a phenotype highly specific to Glanzmann's Thrombasthenia (PMID: 28232155; PP4). cDNA from the patient indicates that the c.574+5G>C splice variant causes the in-frame deletion of Ser160_Ser192 in exon 4, due to loss of the donor site and activation of a new splicing site (PM4; PMID: 21644217). It is absent from population databases (PM2_supporting). In summary, this variant is classified as Likely Pathogenic for autosomal recessive Glanzmann thrombasthenia. GT-specific criteria applied: PM2_supporting, PM3, PM4, PP3, PP4_moderate (PD-VCEP specifications v2.1). |