Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Clin |
RCV001803439 | SCV002047591 | pathogenic | Glanzmann thrombasthenia | 2021-09-03 | reviewed by expert panel | curation | The NM_000419.5:c.625-1G>A variant in ITGA2B occurs within the canonical splice acceptor site of intron 5. It is predicted to cause skipping of biologically-relevant-exon 6/30, resulting in a frameshift (p.(Ala209Valfs*155) with a premature stop codon in exon 12/30 leading to nonsense mediated decay in a gene in which loss-of-function is an established disease mechanism (PVS1). At least one proband has been reported with this variant, GT35 of PMID: 29675921 meets the criteria for PP4_strong. This variant is absent from gnomAD v2.1.1 (PM2_Supporting). In summary, this variant meets the criteria to be classified as Pathogenic for autosomal recessive Glanzmann Thrombasthenia based on the ACMG/AMP criteria applied, as specified by the ClinGen PD VCEP: PVS1, PM2_supporting, PP4_strong. (VCEP specifications version 2; date of approval 09/02/2021) |