ClinVar Miner

Submissions for variant NM_000451.4(SHOX):c.279G>T (p.Gly93=)

dbSNP: rs193922465
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Women's Health and Genetics/Laboratory Corporation of America, LabCorp RCV001642247 SCV000053121 uncertain significance not specified 2024-05-03 criteria provided, single submitter clinical testing Variant summary: SHOX c.279G>T (p.Gly93Gly) alters a non-conserved nucleotide located close to a canonical splice site and therefore could affect mRNA splicing, leading to a significantly altered protein sequence. Consensus agreement among computation tools predict no significant impact on normal splicing. However, these predictions have yet to be confirmed by functional studies. The variant allele was found at a frequency of 8.4e-05 in 249940 control chromosomes. This frequency is not significantly higher than estimated for a pathogenic variant in SHOX causing Short Stature (8.4e-05 vs 0.0005), allowing no conclusion about variant significance. To our knowledge, no occurrence of c.279G>T in individuals affected with Short Stature and no experimental evidence demonstrating its impact on protein function have been reported. ClinVar contains an entry for this variant (Variation ID: 36773). Based on the evidence outlined above, the variant was classified as VUS-possibly benign.
Athena Diagnostics RCV001642247 SCV001145619 benign not specified 2020-09-15 criteria provided, single submitter clinical testing

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