ClinVar Miner

Submissions for variant NM_000455.4(STK11):c.*8C>T (rs587782259)

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Total submissions: 6
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000130973 SCV000185888 uncertain significance Hereditary cancer-predisposing syndrome 2014-09-16 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Insufficient or conflicting evidence,Other data supporting benign classification,Co-occurence with a mutation in another gene that clearly explains a proband's phenotype
Color RCV000130973 SCV000902617 likely benign Hereditary cancer-predisposing syndrome 2015-04-06 criteria provided, single submitter clinical testing
GeneDx RCV000213042 SCV000171898 benign not specified 2014-05-01 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Illumina Clinical Services Laboratory,Illumina RCV000339554 SCV000410750 likely benign Peutz-Jeghers syndrome 2016-06-14 criteria provided, single submitter clinical testing
Mayo Clinic Genetic Testing Laboratories,Mayo Clinic RCV000213042 SCV000692057 uncertain significance not specified no assertion criteria provided clinical testing
PreventionGenetics RCV000679315 SCV000806065 likely benign not provided 2017-01-30 criteria provided, single submitter clinical testing

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